diff --git a/modules/python/common.cmake b/modules/python/common.cmake
index 3c0c4febd7..e9375af2c0 100644
--- a/modules/python/common.cmake
+++ b/modules/python/common.cmake
@@ -59,7 +59,12 @@ endif()
 if(APPLE)
   set_target_properties(${the_module} PROPERTIES LINK_FLAGS "-undefined dynamic_lookup")
 elseif(WIN32 OR OPENCV_FORCE_PYTHON_LIBS)
-  ocv_target_link_libraries(${the_module} PRIVATE ${${PYTHON}_LIBRARIES})
+  if(${PYTHON}_DEBUG_LIBRARIES AND NOT ${PYTHON}_LIBRARIES MATCHES "optimized.*debug")
+    ocv_target_link_libraries(${the_module} PRIVATE ${${PYTHON}_LIBRARIES})
+    ocv_target_link_libraries(${the_module} PRIVATE debug ${${PYTHON}_DEBUG_LIBRARIES} optimized ${${PYTHON}_LIBRARIES})
+  else()
+    ocv_target_link_libraries(${the_module} PRIVATE ${${PYTHON}_LIBRARIES})
+  endif()
 endif()
 
 if(TARGET gen_opencv_python_source)